研究業績Achievements
| 1. | Fujioka M, Itonaga H, Nakazawa H, Nishida T, Kataoka K, Ikeda T, Kako S, Matsuoka KI, Adachi K, Fujiwara SC, Aotsuka N, Kawakita T, Sakaida E, Kanda Y, Ichinohe T, Atsuta Y, Miyazaki Y, Ishiyama K. Superior survival after unrelated allogeneic stem cell transplantation with low-dose ATG compared to low-dose TBI in myeloablative fludarabine/busulfan-based regimen for MDS on behalf of the adult MDS Working Group of the JSTCT. Transplant Cell Ther. 2025 Jan;31(1):18.e1-18.e12. doi: 10.1016/j.jtct.2024.09.026. Epub 2024 Oct 6. |
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| 2. | Mitsuyoshi T, Arai Y, Kondo T, Kawata T, Hirabayashi S, Tanaka M, Mori Y, Doki N, Nishida T, Kotani T, Ogata M, Tabayashi T, Eto T, Sawa M, Imada K, Kanda J, Ichinohe T, Atsuta Y, Yanada M. HLA-matched related peripheral blood stem cell and bone marrow transplantation with RIC regimens yield comparable outcomes for adult AML. EJHaem. 2025 Jan 21;6(1):e21088. doi: 10.1002/jha2.1088. eCollection 2025 Feb. |
| 3. | Tamura Y, Ohki S, Nagai H, Yoshizato R, Nishi S, Jin Y, Kitajima Y, Guo Y, Ichinohe T, Okada S, Kawano Y, Yasuda T. Co-expression of B7-H3 and LAG3 represents cytotoxicity of CD4+ T cells in humans. Front Immunol. 2025 Feb 25;16:1560383. doi: 10.3389/fimmu.2025.1560383. eCollection 2025. |
| 4. | Nakao T, Shindo T, Takakura H, Narita T, Ise-Nakao Y, Akiyama S, Iizumi Y, Boku S, Watanabe M, Sakai T, Shimizu S, Yamada M, Sowa Y, Mutoh M. Trametinib suppresses the stimulated T cells through G1 arrest and apoptosis. Eur J Immunol. 2025 Feb;55(2):e202350667. doi: 10.1002/eji.202350667. |
| 5. | Yoshimoto K, Maeoka Y, Kubota S, Chishaki R, Takahashi A, Osaki Y, Mino T, Ichinohe T, Masaki T. Polycythemia secondary to bilaterally enlarged kidneys in T-Cell acute lymphoblastic leukemia: a case report and literature review. BMC Nephrol. 2025 Mar 6;26(1):121. doi: 10.1186/s12882-025-04032-3. |
| 6. | Yoshida N, Ureshino H, Hiyama T, Harada Y, Nakatani S, Chishaki R, Edahiro T, Yoshida T, Shindo T, Ichinohe T. Tirabrutinib for CNS relapsed primary vitreoretinal lymphoma. Ann Hematol. 2025 Mar;104(3):2073-2074. doi: 10.1007/s00277-025-06284-3. |
| 7. | Nishitani K, Nakamizo S, Shindo T, Kaku Y, Fujimoto M, Hirata M, Mizoguchi K, Kawai K, Kabashima K. Coexistence of oligoclonal and polyclonal HTLV-1-positive T cells with presentation of acute-type adult T-cell leukaemia-lymphoma successfully treated by ultraviolet B phototherapy and etretinate. J Eur Acad Dermatol Venereol. 2025 Apr;39(4):e297-e299. doi: 10.1111/jdv.20284. EPub 2024 Aug 8. |
| 8. | Oshima S, Arai Y, Kondo T, Yano S, Hirabayashi S, Uchida N, Onizuka M, Miyakoshi S, Tanaka M, Takahashi S, Hayashi M, Kawakita T, Uehara Y, Ota S, Izumi T, Sawa M, Nishida T, Katayama Y, Nagafuji K, Kato K, Ichinohe T, Atsuta Y, Yanada M. Myeloablative conditioning in cord blood transplantation for acute myeloid leukemia patients is efficacious only until age 55. Bone Marrow Transplant. 2025 Apr;60(4):458-466. doi: 10.1038 /s41409-025-02508-2. EPub 2025 Jan 21. |
| 9. | Fuji S, Tokunaga M, Kato K, Nakano N, Shindo T (co-author from Kyoto Univ.), Makiyama J, Itonaga H, Ito A, Eto T, Ishikawa J, Hasegawa Y, Ishitsuka K, Moriuchi Y, Ota S, Mori Y, Suehiro Y, Takase K, Kanda Y, Onizuka M, Fukuda T, Atsuta Y, Yoshimitsu M. Significant detrimental impact of pre-transplant mogamulizumab on the post-transplant outcome with a short interval between the last mogamulizumab and transplantation. Bone Marrow Transplant. 2025 Apr;60(4):552-554. doi: 10.1038/s41409-025-02517-1. EPub 2025 Feb 3. |
| 10. | Wada F, Iwasaki M, Hirayama M, Kawamura K, Kaida K, Doki N, Nakamae H, Hasegawa Y, Fukuda T, Eto T, Hiramoto N, Maruyama Y, Nagafuji K, Ota S, Ishikawa J, Ando T, Ichinohe T, Atsuta Y, Nakasone H, Kanda J. Donor selection in T-cell-replete haploidentical donor peripheral blood stem cell transplantation. Leukemia. 2025 Apr;39(4):951-961. doi: 10.1038/s41375-025-02538-1. EPub 2025 Feb 19. |
| 11. | Yokoyama H, Fuji S, Murata M, Hirayama M, Wake A, Uchida N, Tanaka M, Onizuka M, Takahashi S, Doki N, Maruyama Y, Ishiwata K, Uehara Y, Nishida T, Sawa M, Kawakita T, Eto T, Ishimaru F, Kato K, Ichinohe T, Atsuta Y, Terakura S, Morishima S. Impact of graft-versus-host disease on outcomes of cord blood transplantation according to HLA disparity and its prophylaxis type. Ann Hematol. 2025 May;104(5):2905-2913. doi: 10.1007/s00277-025-06415-w. Epub 2025 May 21. |
| 12. | Sawamoto N, Doi D, Nakanishi E, Sawamura M, Kikuchi T, Yamakado H, Taruno Y, Shima A, Fushimi Y, Okada T, Kikuchi T, Morizane A, Hiramatsu S, Anazawa T, Shindo T (京都大学の共著者), Ueno K, Morita S, Arakawa Y, Nakamoto Y, Miyamoto S, Takahashi R, Takahashi J. Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson's disease. Nature. 2025 May; 641(8064):971-977. doi: 10.1038/s41586-025-08700-0. Epub 2025 Apr 16. [プレスリリース] |
| 13. | Ureshino H, Ueshima T, Yamaguchi T, Takashima M, Sanuki Y, Ichinohe T. (R)-WAC-224, a new anticancer quinolone, combined with venetoclax and azacitidine overcomes venetoclax-resistant AML through MCL-1 downregulation. Sci Rep. 2025 May 8;15(1):16018. doi: 10.1038/s41598-025-98534-7. [プレスリリース] |
| 14. | Arai Y, Brazauskas R, He N, Al-Homsi AS, Chhabra S, Battiwalla M, Yanada M, Steinberg A, Diaz Perez MA, Hong S, Kanda J, Bashey A, Frangoul HA, Badawy SM, Verdonck LF, Lazarus HM, Yared JA, Hashem H, Sharma A, Aljurf M, Dias AL, Abid MB, Wirk B, Freytes CO, Zeidan AM, Gergis U, Beitinjaneh A, Askar M, Pu JJ, Lehmann LE, Rangarajan HG, Wood WA, Hashmi S, Yano S, Kako S, Ozawa Y, Doki N, Kanda Y, Fukuda T, Katayama Y, Ichinohe T, Tanaka J, Teshima T, Okamoto S, Atsuta Y, Saber W.Efficacy of Total-Body Irradiation-based Intensified Myeloablative Regimens for Acute Leukemia-An International Collaborative Study. EJHaem. 2025 May 28;6(3):e70061. doi: 10.1002/jha2.70061. |
| 15. | Honjo Y, Ichinohe T. Neural crest cells are sensitive to radiation-induced DNA damage. Tissue Cell. 2025 Jun;94:102774. doi: 10.1016/j.tice.2025.102774. EPub 2025 Feb 5. |
| 16. | Kurosawa S, Fukuda T, Ichinohe T, Hashii Y, Kanda J, Goto H, Kato K, Ishimaru F, Yoshimitsu M, Hino M, Matsuo K, Ito Y, Yanagisawa A, Ohbiki M, Tabuchi K, Atsuta Y, Arai Y; Japanese Society for Transplantation and Cellular Therapy (JSTCT). Center effect on outcomes of second allogeneic hematopoietic stem cell transplantation for B-cell acute lymphoblastic leukemia: a nationwide retrospective study. Cytotherapy. 2025 Jun;27(6):733-743. doi: 10.1016/j.jcyt.2025.03.002. EPub 2025 Mar 12. |
| 17. | Hagino T, Ikegame K, Tanaka H, Kanda Y, Kaida K, Fukuda T, Kondo Y, Sato M, Doki N, Nakamae H, Matsuoka KI, Mori Y, Sano H, Eto T, Kawakita T, Hashii Y, Ichinohe T, Atsuta Y, Kanda J; HLA Working Group of Japanese Society for Transplantation, Cellular Therapy. Engraftment outcome of patients with anti-HLA antibodies in HLA-mismatched peripheral blood stem cell transplantation. Int J Hematol. 2025 Jun;121(6):848-856. doi: 10.1007/s12185-025-03952-y. EPub 2025 Mar 20. |
| 18. | Hirata M, Tsukita K, Shindo T, Yagi S, Ito T, Tanaka S, Fujimoto R, Kayawake H, Nakamura K, Fujiyama N, Saito M, Yurugi K, Hishida R, Kato A, Kawaguchi A, Habuchi T, Kobayashi T, Date H, Hatano E. Cross-organ hierarchy of HLA molecular mismatches in donor-specific antibody development in solid organ transplantations. Cell Rep Med. 2025 Jun 17;6(6):102153. doi: 10.1016/j.xcrm.2025.102153. EPub 2025 May 30. [プレスリリース] |
| 19. | Itonaga H, Fukushima T, Kato K, Muranushi H, Tokunaga M, Fukuda T, Kawakita T, Kato T, Mori Y, Nakachi S, Suehiro Y, Kuriyama T, Fujioka M, Onizuka M, Ichinohe T, Ohbiki M, Atsuta Y, Fuji S, Yoshimitsu M. Bone marrow versus peripheral blood stem cells as the graft source for allogeneic transplantation from HLA-matched relative donors in adult T-cell leukemia/lymphoma: A nationwide retrospective study by the ATL working group of the Japanese Society for Transplantation and Cellular Therapy. Bone Marrow Transplant. 2025 Jun;60(6):906-909. doi: 10.1038/s41409-025-02563-9. Epub 2025 Apr 8. |
| 20. | Kato M, Nakashone H, Matsuo K, Ito Y, Yanagisawa A, Ohbiki M, Tabuchi K, Ichinohe T, Hashii Y, Kanda J, Goto H, Kato K, Yoshimitsu M, Sato A, Hino M, Matsumoto K, Yakushijin K, Atsuta Y, Fukuda T. Impact of center volume on outcomes in allogeneic hematopoietic cell transplantation for children. Bone Marrow Transplant. 2025 Jun;60(6):851-856. doi: 10.1038/s41409-025-02569-3. Epub 2025 Apr 10. |
| 21. | Iwasaki M, Kanda J, Tanaka H, Ikegame K, Shindo T, Kawase T, Yoshihara S, Doki N, Nakamae H, Eto T, Tanaka T, Ara T, Hiramoto N, Kondo Y, Matsuoka KI, Ando T, Shono K, Nagafuji K, Fukuda T, Ichinohe T, Atsuta Y, Murata M, Morishima S. Impact of HLA epitope matching on outcomes in haploidentical HSCT with distinct GVHD prophylaxes Transplantation. 2025 Jul 1;109(7):1241-1250. doi: 10.1097/TP.0000000000005347. EPub 2025 Feb 14. |
| 22. | Kitamura Y, Shimizu S, Kuroda S, Honmyo N, Nakano R, Sakai H, Tahara H, Ohira M, Ide K, Kobayashi T, Ichinohe T, Ohdan H. Durvalumab induced immune-related agranulocytosis after conversion surgery in a patient with intrahepatic cholangiocarcinoma: a case report. Front Immunol. 2025 Jul 11;16:1610190. doi: 10.3389/fimmu.2025.1610190. |
| 23. | Oka T, Nakajima T, Iwasaki M, Takeda J, Torishima M, Sakurada M, Shimizu T, Shindo T (京都大学の共著者), Fujimoto M, Otsuki S, Haga H, Sugano K, Ando M, Mizumoto C, Kanda J, Nannya Y, Ogawa S, Takaori-Kondo A, Kosugi S. The Intersection of Lynch Syndrome and Hematological Malignancies: A Rare Short Report. EJHaem. 2025 Jul 28;6(4):e70116. doi: 10.1002/jha2.70116. eCollection 2025 Aug. |
| 24. | Shimizu T, Shindo T (京都大学の共著者), Ogawa H, Teranaka K, Watanabe A, Takaori-Kondo A. Upregulation of YY1/EZH2 and MLH1 as Therapeutic Targets for Adult T-Cell Leukemia/Lymphoma. Cancer Sci. 2025 Aug;116(8):2163-2175. doi: 10.1111/cas.70095. Epub 2025 May 12. |
| 25. | Zaimoku Y, Imi T, Hatada T, Mizumaki H, Mura H, Yoshino H, Kano Y, Kobayashi M, Morishita E, Fushida N, Matsushita T, Mizuguchi K, Ikeda H, Nannya Y, Ogawa S, Hosomichi K, Doki N, Katayama Y, Koike T, Matsuoka KI, Nishida T, Takahashi Y, Kataoka K, Nakazawa H, Ueda Y, Fukuda T, Ichinohe T, Ishimaru F, Onizuka M, Atsuta Y, Miyamoto T; Japanese Society of Transplantation and Cellular Therapy. Prevalence and outcome of VEXAS syndrome in unrelated hematopoietic cell transplantation for bone marrow failure. Clin Exp Med. 2025 Aug 22;25(1):300. doi: 10.1007/s10238-025-01832-7. |
| 26. | Nakata Y, Ueda T, Sera Y, Koizumi M, Imamura K, Kanai A, Ikeda KI, Yamasaki N, Nagamachi A, Kobatake K, Taguchi M, Sotomaru Y, Ichinohe T, Honda ZI, Nakamura T, Manabe I, Suda T, Takubo K, Kaminuma O, Honda H. JMJD3-mediated senescence is required to overcome stress-induced hematopoietic defects. EMBO Rep. 2025 Aug;26(15):3831-3855. doi: 10.1038/s44319-025-00502-9. Epub 2025. Jun 25. |
| 27. | Morizane A, Yamasaki E, Shindo T (京都大学の共著者), Anazawa T, Sawamoto N, Shima A, Yamakado H, Nakanishi E, Sawamura M, Taruno Y, Doi D, Kikuchi T, Kawasaki Y, Saito MK, Kikuchi T, Arakawa Y, Miyamoto S, Nakamoto Y, Takahashi R, Takahashi J. Control of immune response in an iPSC-based allogeneic cell therapy clinical trial for Parkinson's disease. Cell Stem Cell. 2025 Sep 4;32(9):1346-1355.e3. doi: 10.1016/j.stem.2025.07.012. Epub 2025 Aug 19. |
| 28. | Edahiro T, Yoshida T, Nakatani S, Ureshino H, Ichinohe T. Successful Treatment of Lymphoplasmacytic Lymphoma/Waldenström Macroglobulinemia Complicated by Severe Autoimmune Neutropenia With Rituximab and Bendamustine. Cureus. 2025 Sep 28;17(9):e93392. doi: 10.7759/cureus.93392. eCollection 2025 Sep. |
| 29. | Omori K, Kitagawa H, Takamori A, Yoshida T, Omoto T, Nomura T, Kubo Y, Shigemoto N, Akita T, Orihashi Y, Ichinohe T, Hattori N, Ohge H. Antiviral combination therapy in severely immunocompromised patients with persistent or recurrent COVID-19. J Infect Chemother. 2025 Oct;31(10):102802. doi: 10.1016/j.jiac.2025.102802. Epub 2025 Aug 26. |
| 30. | Okuda Y, Nakamura S, Ishii Y, Tatsukawa Y, Ikemoto J, Miyamoto S, Furukawa M, Nakamura K, Iijima N, Nomura R, Yoshida T, Ichinohe T, Oka S. Methotrexate-associated lymphoproliferative disorder presenting as obstructive jaundice due to pancreatic involvemen.t Intern Med. 2025 Dec 1;64(23):3387-3394. doi: 10.2169/internalmedicine. 5609-25. Epub 2025 May 29. |
| 31. | Itonaga H, Miyazaki Y, Fujioka M, Kurosawa S, Nagata Y, Shimazu Y, Ueda T, Uchida N, Doki N, Nishida T, Asada N, Tanaka M, Takada S, Sakurai M, Kurokawa M, Yoshimitsu M, Kanda Y, Ichinohe T, Atsuta Y, Tachibana T; adult MDS and CML/MPN working groups of the Japanese Society for Transplantation and Cellular Therapy. Differential impact of graft-versus-host disease on post-transplant outcomes of chronic myelomonocytic leukemia according to transplant procedures. Leuk Res. 2025 Dec;159:108134. doi: 10.1016/j.leukres.2025.108134. Epub 2025 Nov 5. |
| 32. | Zaimoku Y, Yamazaki H, Kanaya M, Hiramoto N, Ishiyama K, Takenaka K, Murata M, Uchida N, Doki N, Yamamoto R, Nishida T, Onodera K, Machida S, Kanda Y, Eto T, Kataoka K, Asada N, Itagaki M, Sakata-Yanagimoto M, Ishimaru F, Onizuka M, Ichinohe T, Atsuta Y, Onishi Y. Loss-Prone HLA Class I Alleles Inform Outcomes of Early Hematopoietic Cell Transplantation in Acquired Aplastic Anemia. Am J Hematol. 2025 Dec;100(12):2195-2208. doi: 10.1002/ajh.70054. Epub 2025 Sep 5. |
| 33. | Maegaki M, Takahashi T, Suzuki K, Minakata D, Terao T, Satake A, Akira H, Oyake T, Kanda Y, Aotsuka N, Tsukada N, Tabayashi T, Kobayashi H, Nawa Y, Ichinohe T, Ohbiki M, Atsuta Y, Kawamura K. Comparison of Autologous and Allogeneic Hematopoietic Stem Cell Transplantation for Primary Plasma Cell Leukemia in Japan. Transplant Cell Ther. 2025 Dec;31(12):1031.e1-1031.e11. doi: 10.1016/j.jtct.2025.08.026. Epub 2025 Sep 8. |